Division of Functional Materials Chemistry
State Scientific Institution “Institute for Single Crystals”
of National Academy of Sciences of Ukraine

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Selected publications

Regulatory Documents

  1. Ministry of Health of Ukraine Regulation ST-N MOHU 42-3.0:2011. – Medicinal Products. Pharmaceutical development (ICH Q8) / M. Lyapunov, O. Bezugla, Yu. Pidpruzhnykov et al. // Standartization of pharmaceutical products. – Kyiv, MOH of Ukraine, 2012. – p. 19-56.

  2. Ministry of Health of Ukraine Regulation ST-N MOHU 42-3.8:2013. – Medicinal Products. Pharmaceutical quality of inhalation and nasal drugs. / O. Bezugla, M.Lyapunov, O. Solov`yov. – Kyiv, MOH of Ukraine. – 2013. – 52 p.
    http://www.moz.gov.ua/ua/portal/dn_20130518_0398.html

  3. Ministry of Health of Ukraine Regulation ST-N MOHU 42-5.0:2014. – Medicinal Products. GDP/ M.Lyapunov, O.Bezugla, M.Pasichnyk et al. – Kyiv, MOH of Ukraine, 2014. – 51 p.
    http://uphig.org/service/moz/moz_27082014

  4. Ministry of Health of Ukraine Regulation ST-N MOHU 42-4.0:2014. – Medicinal Products. GMP / M.Lyapunov, O.Bezugla, M.Pasichnyk et al. – Kyiv, MOH of Ukraine, 2014. – 321 p.
    http://uphig.org/service/moz/moz_17072014-2

  5. Ministry of Health of Ukraine Regulation ST-N MOHU 42-3.9:2014. – Medicinal Products. Impurities in New Drug Substances and New Drug Products / M. Lyapunov, O. Antipova, O. Baula et al. Kyiv, MoH of Ukraine, 2014, 34 p. (In Ukrainian)

    http://www.moz.gov.ua/docfiles/dn_20141128_0903_dod.pdf

  6. Ministry of Health of Ukraine Regulation ST-N MOHU 42-4.0:2016. – Medicinal Products. Good Manufacturing Practice / M. Lyapunov, O. Bezugla, N. Tahtaulova et al. Kyiv, MoH of Ukraine, 2016, 357 p. (In Ukrainian)

    http://www.diklz.gov.ua/doccatalog/document?id=823529

  7. Ministry of Health of Ukraine Regulations. Standardization of the Pharmaceutical Products / M. Lyapunov, O. Bezugla, Yu. Pidpruzhnykov et al. Kyiv, MoH of Ukraine, MORION, 2016, V. 1, 982 p. (In Ukrainian)

Original articles

  1. N.A.Lyapunov, E.P.Bezuglaya, Yu.M.Stolper, V.A.Bovtenko, A.N.Lyapunova, E.G. Zhemerova, I.A.Zinchenko. Chapter 9. Pharmaceutical development of medicinal products. // Analytical chemistry in the development, standardization and quality control of drugs. / Edited by V.P.Georgievsky. – Vol. 3. Metrological and regulation supplement of the development, production and quality control of drugs. – Kharkov: «NTMT», 2012. – p. 1419-1512. (In Russian)

  2. N.A.Lyapunov, AV.Purtov, E.V.Dunai. Surfactant, colloid micellar and antibacterial properties of some cation antibioticvs. // Pharmacy. – 2013. – Vol 4. – p. 44-47. (In Russian)

  3. Y.O. Butko, S.M. Drogovoz, N.O. Lyapunov. The studies on effect of wound-healing preparations on the protein metabolism indices and the circulating immune complex in burn trauma // European Applied Sciences. Section 6. Medical Science. – 2013. – 6-1. – P. 52-54.

  4. E.P. Bezuglaya, A.N. Lyapunova, A.P. Krasnoperova. Water – Hexylene Glycol System as a Potential Medicinal Base // Pharmaceutical Chemistry Journal. – 2013. – Vol. 47, No 5. – P. 281-286.

  5. Krasnoperova A.P., Yukhno G.D., Lyapunov A.N., Bezuglaya E.P. Volumetric properties of bicomponent system methylpyrrolidone-ethanol // Kharkov National University Journal. – 2013. – Vol 1085. – Khimiya. – Issue. 22 (45). – p. 142-149. (In Russian)

  6. N.A.Lyapunov, E.P.Bezuglaya. Methodology of pharmceutical development of medicinal products in Ukraine. // Pharmacy. – 2013. – Vol 7. – p. 44-49. (In Russian)

  7. Semi-solid preparations: pharmaceutical development and technology transfer / Lyapunov N.A., Bezuglaya E.P., Zinchenko I.A., Lyapunov A.N., Stolper Yu.M. // Pharmaceutical industry, 2014, No 5 (46), 22-33. (In Russian)

  8. А comparative study of bioavailability and other pharmacokinetic parameters of ketorolac administered as nasal sprays and solution for injection in rabbits / V.V. Libina, E.P. Bezuglaya, О.V. Тymchenko, N.A. Lyapunov, I. N. Orlova, I.V. Kudris – Belgorod State University Scientific bulletin. Medicine. Pharmacy, 2014, No 24 (195), issue 28, 246-253. (In Russian)

  9. A. N. Lyapunov, E. P. Bezuglaya, N. A. Lyapunov, I. A. Kirilyuk, Studies of carbomer gels using rotational viscometry and spin probes – Pharmaceutical Chemistry Journal, 2015, Vol. 49, No 9, 639-644.

  10. Effect of different particle size reduction techniques on the nefopam and acyclovir dispersity / Pinchukova N.A., Lyapunov N.A., Bezuglaya E.P., Voloshko A.Yu., Lyapunov A.N., Merko V.A., Chebanov V.A. // Functional Materials, 2015, Vol. 22, No 4, 535-542.

  11. Evaluation of uniformity of active substance and excipients distribution in semi-solid preparations / Lyapunov N.A., Zinchenko I.A., Bezuglaya E.P. // Pharmacom, 2015, No 2, 33-40. (In Russian)

  12. The influence of glucosamine and Ketoprofen combination in the form of cream-gel on connective tissue metabolism indicators of rats with experimental osteoarthritis / Davishnia N.V., Zupanets I.A., Shebeko S.K., Lyapunov M.O. // The Pharma Innovation Journal, 2015, 3(12), 08-11.

  13. A.N. Lyapunov, E.P. Bezuglaya. I.A. Zinchenko. Analytical support for the development of manufacturing process of the meloxicam gel // Pharmacom, 2015, No 3/4, 29-38. (In Russian)

  14. Rationale for a new approach to quality evaluation of pressurised metered-dose preparations for inhalationat the development stage / N.A. Lyapunov, V.A. Bovtenko, E.P. Bezuglaya, Y.M. Stolper – Belgorod State University Scientific bulletin. Medicine. Pharmacy, 2016, No 5 (226), issue 33, 170-179. (In Russian)

  15. N.A. Lyapunov, E.P. Bezuglaya, A.N. Lyapunov. Using of the dispersing equipment Megatron ® for technology of emulsions and suspensions // Development and registration of medicinal products, 2016, No 4 (17), 260-265. (In Russian)

  16. O. P. Bezugla, A. M. Lyapunova, I. A. Kirilyuk, O. M. Lyapunov. The study of steroid distribution in emulsions by the spin probe method // Klinicna Farmacia, 2017, Vol. 21, No 3, 47-54.

  17. I.A. Zinchenko, N.A. Lyapunov, E.P. Bezuglaya. Validation of the analytical procedure for an assay of ketoprofen impurities by liquid chromatography // Pharmacom, 2017, No 3, 25-32. (In Russian)